Evidence that hPIV2 paramyxovirus antigenomes are edited during infection

• Published in: mBio Vol. 16; no. 8; p. e0366724
• Main Authors: Ohta, Keisuke, Kawasaki, Junna, Kolakofsky, Daniel, Nishio, Machiko, Matsumoto, Yusuke
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 24.06.2025
• Subjects: Genome, Viral; Humans; Opinion/Hypothesis; Parainfluenza Virus 2, Human - genetics; Parainfluenza Virus 2, Human - physiology; paramyxovirus; RNA Editing; RNA, Messenger - genetics; RNA, Viral - genetics; rule of six; viral replication; Virology; Virus Replication; viral replication; rule of six; RNA editing; paramyxovirus

We have assumed that paramyxovirus editing signals would operate strictly during mRNA synthesis, as it apparently makes no sense to edit antigenomes. Nevertheless, there is evidence here that the opposite is the case. If so, this alters our view of paramyxovirus replication, and we summarize what is...