Evidence that hPIV2 paramyxovirus antigenomes are edited during infection

We have assumed that paramyxovirus editing signals would operate strictly during mRNA synthesis, as it apparently makes no sense to edit antigenomes. Nevertheless, there is evidence here that the opposite is the case. If so, this alters our view of paramyxovirus replication, and we summarize what is...

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Published inmBio Vol. 16; no. 8; p. e0366724
Main Authors Ohta, Keisuke, Kawasaki, Junna, Kolakofsky, Daniel, Nishio, Machiko, Matsumoto, Yusuke
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 24.06.2025
Subjects
Genome, Viral
Humans
Opinion/Hypothesis
Parainfluenza Virus 2, Human - genetics
Parainfluenza Virus 2, Human - physiology
paramyxovirus
RNA Editing
RNA, Messenger - genetics
RNA, Viral - genetics
rule of six
viral replication
Virology
Virus Replication
viral replication
rule of six
RNA editing
paramyxovirus
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Summary:We have assumed that paramyxovirus editing signals would operate strictly during mRNA synthesis, as it apparently makes no sense to edit antigenomes. Nevertheless, there is evidence here that the opposite is the case. If so, this alters our view of paramyxovirus replication, and we summarize what is known about how its RNA-dependent RNA polymerase carries out its task of expressing alternate open reading frames during mRNA synthesis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Yusuke Matsumoto receives compensation from Denka Co., Ltd. The other authors declare no competing interest.
ISSN:2150-7511
2150-7511
DOI:10.1128/mbio.03667-24