Antimicrobial/Biocompatible Hydrogels Dual-Reinforced by Cellulose as Ultrastretchable and Rapid Self-Healing Wound Dressing

Hydrogels as a wound dressing, integrated with ultrastretchability, rapid self-healing, and excellent antimicrobial activity, are in high demand, particularly for joint skin wound healing. Herein, a multifunctional and ductile composite hydrogel was developed using poly­(vinyl alcohol) (PVA)-borax g...

Full description

Saved in:
Bibliographic Details
Published inBiomacromolecules Vol. 22; no. 4; pp. 1654 - 1663
Main Authors Zhong, Yajie, Seidi, Farzad, Li, Chengcheng, Wan, Zhangmin, Jin, Yongcan, Song, Junlong, Xiao, Huining
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 12.04.2021
Subjects
antimicrobial properties
biocompatibility
biodegradability
borates
carboxymethylcellulose
cellulose nanofibers
crosslinking
hydrogels
hydrogen
imines
neomycin
oxidation
Online AccessGet full text

Cover

More Information
Summary:Hydrogels as a wound dressing, integrated with ultrastretchability, rapid self-healing, and excellent antimicrobial activity, are in high demand, particularly for joint skin wound healing. Herein, a multifunctional and ductile composite hydrogel was developed using poly­(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF). Moreover, neomycin (NEO), an aminoglycoside antibiotic with multifunctional groups, was incorporated into the hydrogel network as both an antibacterial agent and a cross-linker. The dynamic reversible borate ester linkages and hydrogen bonds between OCMC-DA, PVA, and CNF, along with dynamic cross-linking imine linkages between NEO and OCMC-DA, endowed the hydrogel with excellent self-healing ability and stretchability (3300%). The as-reinforced networks enhanced the mechanical properties of hydrogels significantly. More remarkably, the composite hydrogel with improved biodegradability and biocompatibility is pH-responsive and effective against a broad spectrum of bacteria, which is attributed to the controllable release of NEO for steady availability of the antibiotic on the wound location. Overall, the antimicrobial hydrogel with rapid self-healing and reliable mechanical properties holds significant promise as dressing material for wound healing.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1525-7797
1526-4602
1526-4602
DOI:10.1021/acs.biomac.1c00086