Gram Scalable Method to Synthesize Biscarbodiimides and Asymmetric Monocarbodiimides: A Platform to Access an Array of Phosphaguanidines, Amidines, and Guanidines

A mild, broadly functional group tolerant methodology has been developed to access a variety of mono- and bis-carbodiimides in good yield and high purity on multigram scale. Direct addition into these versatile motifs facilitated the rapid synthesis of a library of novel amidinines, guanidines, and...

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Bibliographic Details
Published inJournal of organic chemistry Vol. 87; no. 4; pp. 2022 - 2044
Main Authors Camelio, Andrew M., Krasovskiy, Arkady, Bailey, Brad, Davis, Anna
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 18.02.2022
Amer Chemical Soc
Subjects
Amidines
Carbodiimides
Chemistry
Chemistry, Organic
Guanidine
Guanidines
Molecular Structure
Physical Sciences
Science & Technology
COORDINATION CHEMISTRY
ZIRCONIUM
LIGANDS
COMPLEXES
ELIMINATION
POLYETHYLENE
CARBODIIMIDES
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Summary:A mild, broadly functional group tolerant methodology has been developed to access a variety of mono- and bis-carbodiimides in good yield and high purity on multigram scale. Direct addition into these versatile motifs facilitated the rapid synthesis of a library of novel amidinines, guanidines, and phosphaguandines.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.1c01281