Liposome-Mediated in Situ Formation of AgI/Ag/BiOI Z‑Scheme Heterojunction on Foamed Nickel Electrode: A Proof-of-Concept Study for Cathodic Liposomal Photoelectrochemical Bioanalysis

• Published in: Analytical chemistry (Washington) Vol. 91; no. 6; pp. 3800 - 3804
• Main Authors: Yu, Si-Yuan, Mei, Li-Ping, Xu, Yi-Tong, Xue, Tie-Ying, Fan, Gao-Chao, Han, De-Man, Chen, Guangxu, Zhao, Wei-Wei
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 19.03.2019
• Subjects: Chemistry; Electrodes; Heterojunctions; Liposomes; Nanoparticles; Nickel; Silver
• ISSN: 0003-2700; 1520-6882
• DOI: 10.1021/acs.analchem.9b00352

This work reports the liposome-mediated in situ formation of the AgI/Ag/BiOI Z-scheme heterojunction on foamed nickel electrode for signal-on cathodic photoelectrochemical (PEC) bioanalysis. Specifically, in a proof-of-concept study, Ag nanoparticle-encapsulated liposomes were initially confined via the sandwich immunobinding and then processed to release numerous Ag+ ions, which were then directed to react with the BiOI/Ni electrode, resulting in the in situ generation of a AgI/Ag/BiOI Z-scheme heterojunction on the electrode. The enhanced cathodic signal could be correlated to the target concentration, which thus underlays a novel signal-on cathodic liposomal PEC bioanalysis strategy. Different from previous anodic liposomal PEC bioanalysis, this work features the first cathodic liposomal PEC bioanalysis on the basis of the in situ formation of a Z-scheme heterojunction. More generally, integrated with various biorecognition events, this protocol could serve as a common basis for addressing numerous targets of interest.