Progressive neuropsychiatric symptoms and motor impairment

• Published in: JAMA neurology Vol. 71; no. 6; p. 794
• Main Authors: Ghadiri, Mahtab, Buckland, Michael E, Sutton, Ian J, Al Jahdhami, Suad, Flanagan, Simon, Heard, Robert, Barnett, Yael, Brennan, Jeffrey, Barnett, Michael H
• Format: Journal Article
• Language: English
• Published: United States 01.06.2014
• Subjects: Adult; Atrophy - complications; Axons - pathology; Brain - pathology; Cognition Disorders - diagnosis; Cognition Disorders - etiology; Diffusion Tensor Imaging - methods; Disease Progression; Humans; Male

A 42-year-old white man presented with cognitive impairment and behavioral changes followed by rapidly progressive motor and gait impairment. Magnetic resonance imaging revealed striking multifocal white matter signal change, areas of restricted diffusion, diffuse callosal signal change, and atrophy...