Progressive neuropsychiatric symptoms and motor impairment

A 42-year-old white man presented with cognitive impairment and behavioral changes followed by rapidly progressive motor and gait impairment. Magnetic resonance imaging revealed striking multifocal white matter signal change, areas of restricted diffusion, diffuse callosal signal change, and atrophy...

Full description

Saved in:
Bibliographic Details
Published inJAMA neurology Vol. 71; no. 6; p. 794
Main Authors Ghadiri, Mahtab, Buckland, Michael E, Sutton, Ian J, Al Jahdhami, Suad, Flanagan, Simon, Heard, Robert, Barnett, Yael, Brennan, Jeffrey, Barnett, Michael H
Format Journal Article
LanguageEnglish
Published United States 01.06.2014
Subjects
Adult
Atrophy - complications
Axons - pathology
Brain - pathology
Cognition Disorders - diagnosis
Cognition Disorders - etiology
Diffusion Tensor Imaging - methods
Disease Progression
Humans
Male
Online AccessGet more information

Cover

More Information
Summary:A 42-year-old white man presented with cognitive impairment and behavioral changes followed by rapidly progressive motor and gait impairment. Magnetic resonance imaging revealed striking multifocal white matter signal change, areas of restricted diffusion, diffuse callosal signal change, and atrophy and hyperintensity of the corticospinal tracts. A broad range of etiologies warrant consideration in this case, including degenerative, vascular, inflammatory, metabolic, and neoplastic diseases.
ISSN:2168-6157
DOI:10.1001/jamaneurol.2013.6308