Evolution and transmission of antibiotic resistance is driven by Beijing lineage Mycobacterium tuberculosis in Vietnam

Drug-resistant tuberculosis (TB) infection is a growing and potent concern, and combating it will be necessary to achieve the WHO's goal of a 95% reduction in TB deaths by 2035. While prior studies have explored the evolution and spread of drug resistance, we still lack a clear understanding of...

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Published inMicrobiology spectrum Vol. 11; no. 6; p. e0256223
Main Authors Silcocks, Matthew, Chang, Xuling, Thuong Thuong, Nguyen Thuy, Qin, Youwen, Minh Ha, Dang Thi, Khac Thai, Phan Vuong, Vijay, Srinivasan, Anh Thu, Do Dang, Ngoc Ha, Vu Thi, Ngoc Nhung, Hoang, Huu Lan, Nguyen, Quynh Nhu, Nguyen Thi, Edwards, David, Nath, Artika, Pham, Kym, Duc Bang, Nguyen, Hong Chau, Tran Thi, Thwaites, Guy, Heemskerk, A Dorothee, Chuen Khor, Chiea, Teo, Yik Ying, Inouye, Michael, Ong, Rick Twee-Hee, Caws, Maxine, Holt, Kathryn E, Dunstan, Sarah J
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 12.12.2023
Subjects
Antimicrobial Chemotherapy
antimicrobial resistance
Mycobacterium tuberculosis
pathogen genomics
Research Article
Mycobacterium tuberculosis
antimicrobial resistance
pathogen genomics
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Summary:Drug-resistant tuberculosis (TB) infection is a growing and potent concern, and combating it will be necessary to achieve the WHO's goal of a 95% reduction in TB deaths by 2035. While prior studies have explored the evolution and spread of drug resistance, we still lack a clear understanding of the fitness costs (if any) imposed by resistance-conferring mutations and the role that genetic lineage plays in determining the likelihood of resistance evolution. This study offers insight into these questions by assessing the dynamics of resistance evolution in a high-burden Southeast Asian setting with a diverse lineage composition. It demonstrates that there are clear lineage-specific differences in the dynamics of resistance acquisition and transmission and shows that different lineages evolve resistance via characteristic mutational pathways.
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Matthew Silcocks, Xuling Chang, and Nguyen Thuy Thuong Thuong contributed equally to this article. Author order was determined by the level of contribution.
Kathryn E. Holt and Sarah J. Dunstan contributed equally to this article.
The authors declare no conflict of interest.
Deceased: David Edwards passed away during the preparation of this manuscript.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.02562-23