Linearized Equations for the Reduced Ion Mobilities of Polar Aliphatic Organic Compounds

• Published in: Analytical chemistry (Washington) Vol. 82; no. 1; pp. 427 - 431
• Main Authors: Hariharan, Chandrasekhara B, Baumbach, Jörg I, Vautz, Wolfgang
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.01.2010
• Subjects: Analytical chemistry; Chemical compounds; Chemistry; Exact sciences and technology; Ions; Linear equations; Mass spectrometry; Organic chemicals; Spectrometric and optical methods; Human; Ion collision; Aliphatic compound; Air; Polar compound; Retention time; Carbon; Accuracy; Synthetic medium; Ion mobility; Simultaneous measurement; Ion spectrometry; Homologous series; Mass spectrometry; Comparative study; Molecule collision; Organic compounds
• ISSN: 0003-2700; 1520-6882
• DOI: 10.1021/ac902459m

Over the years, ion mobility spectrometry has evolved into a powerful technique for rapid identification of analytes in very complex sample matrixes such as human breath. Every analyte detected has a characteristic ion mobility value (and a retention time when additional preseparation techniques are employed) which is used to identify the peaks in a spectrum either by comparison with reference analytes or by simultaneous mass spectrometric measurements. In this study, the mass-mobility correlations between compounds in three different homologous series are used to predict the mobilities of the other substances in the same series in a medium of synthetic air. The results show a very high accuracy (>99.5%) of the prognosis. The linear trend equations of ion mobilities, as a function of the number of carbon atoms, obtained from the different series were then generalized into one linear equation for the reduced ion mobility for the polar aliphatic compounds and is validated by comparing it with the traditional Mason-Schamp equation. To compare the empirical equation obtained from the prognosis and the Mason−Schamp equation, the collision integral term in the latter was split into two terms to linearize it. The resulting novel ion mobility equation could be the starting step to completely describe the relationship between ion collision integral and the ion mobility for polar aliphatic compounds. The splitting of the collision integral into two terms will also give new inputs to describe the various ion models and the different forces that act on the ions and the neutral gas molecules upon which the collision integral is dependent on. This prognosis method could, furthermore, be extended to all other classes of organic compounds and could serve as a useful tool for identification of unknowns in ion mobility spectra, thereby considerably reducing the time-consuming and costly reference measurements and other coupling techniques that are currently employed.