Effect of Vitamin D and/or Calcium Supplementation on Pancreatic β‑Cell Function in Subjects with Prediabetes: A Randomized, Controlled Trial

So far, the potential role of vitamin D in β-cell function remains a matter of debate. Therefore, a randomized, placebo-controlled trial (RCT) was conducted to evaluate the effect of a vitamin D supplement with or without calcium on β-cell function in a Chinese population with prediabetes. Two hundr...

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Published inJournal of agricultural and food chemistry Vol. 71; no. 1; pp. 347 - 357
Main Authors Zhang, Dongdong, Zhong, Xiaoqin, Cheng, Cheng, Su, Zhiwei, Xue, Yuan, Liu, Yaping, Zhang, Yujing, Feng, Mingming, Xu, Ze, Zhao, Tong, Zhang, Luoya, Huang, Haoyue, Li, Wenjie, Li, Xing
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 11.01.2023
Subjects
Bioactive Constituents, Metabolites, and Functions
blood serum
Calcium
Calcium, Dietary
Cholecalciferol
Dietary Supplements
Double-Blind Method
food chemistry
Humans
insulin
Insulin Resistance
Insulin-Secreting Cells
oral administration
Prediabetic State - drug therapy
secretion
Vitamin D
Vitamins
calcium
insulin secretion
vitamin D
prediabetes
trial
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Summary:So far, the potential role of vitamin D in β-cell function remains a matter of debate. Therefore, a randomized, placebo-controlled trial (RCT) was conducted to evaluate the effect of a vitamin D supplement with or without calcium on β-cell function in a Chinese population with prediabetes. Two hundred and forty-three subjects were randomly assigned in a 2-by-2 factorial-design RCT to receive either 1600 IU/day vitamin D3 with/or 500 mg/day calcium for 24 weeks. The results showed that oral administration of vitamin D and calcium could increase the secretion of insulin. Vitamin D-insufficient individuals displayed an increment in the disposition index (adjusted change = 0.31, 95%CI: 0.07, 0.56) after treatment by vitamin D + calcium. It illustrated that supplementation with vitamin D and calcium might improve the function of pancreatic β-cell in prediabetes with low serum 25­(OH)­D levels. However, further studies are needed to confirm the findings. Given the low vitamin D content in natural foods, it is necessary to fortify processed foods with vitamin D.
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ISSN:0021-8561
1520-5118
1520-5118
DOI:10.1021/acs.jafc.2c05469