Multifunctional PLGA/Parylene C Coating for Implant Materials: An Integral Approach for Biointerface Optimization

• Published in: ACS applied materials & interfaces Vol. 8; no. 34; pp. 22093 - 22105
• Main Authors: Golda-Cepa, M, Chorylek, A, Chytrosz, P, Brzychczy-Wloch, M, Jaworska, J, Kasperczyk, J, Hakkarainen, M, Engvall, K, Kotarba, A
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 31.08.2016
• Subjects: biointerface; Coated Materials, Biocompatible; coating; controlled drug elution; implant; Lactic Acid - chemistry; MG-63; oxygen plasma; parylene C; PLGA; Polyglycolic Acid - chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Xylenes; controlled drug elution; coating; oxygen plasma; PLGA; implant; biointerface; parylene C; MG-63
• ISSN: 1944-8244; 1944-8252; 1944-8252
• DOI: 10.1021/acsami.6b08025

Functionalizing implant surfaces is critical for improving their performance. An integrated approach was employed to develop a multifunctional implant coating based on oxygen plasma-modified parylene C and drug-loaded, biodegradable poly­(dl-lactide-co-glycolide) (PLGA). The key functional attributes of the coating (i.e., anti-corrosion, biocompatible, anti-infection, and therapeutic) were thoroughly characterized at each fabrication step by spectroscopic, microscopic, and biologic methods and at different scales, ranging from molecular, through the nano- and microscales to the macroscopic scale. The chemistry of each layer was demonstrated separately, and their mutual affinity was shown to be indispensable for the development of versatile coatings for implant applications.