Treatment of Retinoblastoma in 2015: Agreement and Disagreement

The management of intraocular retinoblastoma is rapidly changing, and even recent reviews on the subject are behind existing practices. The 4 authors of this report collectively represent their management strategies with an emphasis on areas of agreement and disagreement. Ophthalmic artery chemosurg...

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Bibliographic Details
Published inJAMA ophthalmology Vol. 133; no. 11; p. 1341
Main Authors Abramson, David H, Shields, Carol L, Munier, Francis L, Chantada, Guillermo L
Format Journal Article
LanguageEnglish
Published United States 01.11.2015
Subjects
Antineoplastic Agents - administration & dosage
Brachytherapy
Cryotherapy
Eye Enucleation
Humans
Infusions, Intra-Arterial
Intravitreal Injections
Laser Coagulation
Ophthalmic Artery
Retinal Neoplasms - pathology
Retinal Neoplasms - therapy
Retinoblastoma - pathology
Retinoblastoma - therapy
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Summary:The management of intraocular retinoblastoma is rapidly changing, and even recent reviews on the subject are behind existing practices. The 4 authors of this report collectively represent their management strategies with an emphasis on areas of agreement and disagreement. Ophthalmic artery chemosurgery and intravitreous chemotherapy have completely replaced external beam radiotherapy, reduced the use of systemic chemotherapy, and diminished enucleations by 90% without evidence of compromising patient survival.
ISSN:2168-6173
DOI:10.1001/jamaophthalmol.2015.3108