Discovery of a novel class of orally active, non-peptide angiotensin II antagonists

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Bibliographic Details
Published inJournal of medicinal chemistry Vol. 35; no. 20; pp. 3714 - 3717
Main Authors De, B, Winn, M, Zydowsky, T. M, Kerkman, D. J, DeBernardis, J. F, Lee, J, Buckner, S, Warner, R, Brune, M
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.10.1992
Subjects
Administration, Oral
Angiotensin II - antagonists & inhibitors
Animals
Biphenyl Compounds - administration & dosage
Biphenyl Compounds - chemical synthesis
Biphenyl Compounds - pharmacokinetics
Imidazoles - administration & dosage
Imidazoles - chemical synthesis
Imidazoles - pharmacokinetics
Losartan
Pyrimidines - administration & dosage
Pyrimidines - chemical synthesis
Pyrimidines - pharmacokinetics
Rats
Rats, Inbred SHR
Rats, Sprague-Dawley
Structure-Activity Relationship
Tetrazoles - administration & dosage
Tetrazoles - chemical synthesis
Tetrazoles - pharmacokinetics
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ISSN:0022-2623
1520-4804
DOI:10.1021/jm00098a018