Palladium Catalyzed Annulation of o‑Iodo-Anilines with Propargyl Alcohols: Synthesis of Substituted Quinolines

A palladium catalyzed annulation of o-iodo-anilines with propargyl alcohols for the synthesis of substituted quinolines has been developed. The reaction tolerates diverse functional groups under mild conditions, providing direct access to 2,4-disubstituted quinolines from easily available starting m...

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Bibliographic Details
Published inJournal of organic chemistry Vol. 88; no. 16; pp. 12054 - 12063
Main Authors Zhang, Zhi, Deng, Jing-Tong, Feng, Jia-Yi, Liang, Jin-Yan, Xu, Xue-Tao, Peng, Jin-Bao
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 18.08.2023
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
organic chemistry
palladium
Physical Sciences
quinolines
Science & Technology
ACTIVE QUINOLINE
QUINAZOLINE
2-IODOANILINES
ANALOGS
HALOGENATION
INHIBITORS
ALKYNES
CYCLIZATION
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ISSN0022-3263
1520-6904
1520-6904
DOI10.1021/acs.joc.3c01451

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Summary:A palladium catalyzed annulation of o-iodo-anilines with propargyl alcohols for the synthesis of substituted quinolines has been developed. The reaction tolerates diverse functional groups under mild conditions, providing direct access to 2,4-disubstituted quinolines from easily available starting materials. A broad range of 2,4-disubstituted quinolines were efficiently prepared in good to excellent yields.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-3263
1520-6904
1520-6904
DOI:10.1021/acs.joc.3c01451