Histologic features of human orbicularis oculi treated with botulinum A toxin

To evaluate muscle histologic features in humans following therapeutic botulinum toxin injections, we studied orbicularis oculi from 11 patients with blepharospasm; nine had previously received botulinum toxin injections and two had not. All muscles had comparable variability in muscle fiber diamete...

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Bibliographic Details
Published inArchives of ophthalmology (1960) Vol. 109; no. 3; p. 393
Main Authors Harris, C P, Alderson, K, Nebeker, J, Holds, J B, Anderson, R L
Format Journal Article
LanguageEnglish
Published United States 01.03.1991
Subjects
Adult
Aged
Blepharospasm - drug therapy
Blepharospasm - pathology
Botulinum Toxins - therapeutic use
Female
Humans
Male
Middle Aged
Oculomotor Muscles - drug effects
Oculomotor Muscles - pathology
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Summary:To evaluate muscle histologic features in humans following therapeutic botulinum toxin injections, we studied orbicularis oculi from 11 patients with blepharospasm; nine had previously received botulinum toxin injections and two had not. All muscles had comparable variability in muscle fiber diameter, with no necrosis, inflammation, denervation, or consistent alterations in muscle fiber internal architecture. Botulinum toxin produces no persistent histologic changes in human muscle fibers.
ISSN:0003-9950
DOI:10.1001/archopht.1991.01080030095046