Impact of Respiratory Virus Infections on Persons With Chronic Underlying Conditions

• Published in: JAMA : the journal of the American Medical Association Vol. 283; no. 4; pp. 499 - 505
• Main Authors: Glezen, W. Paul, Greenberg, Stephen B, Atmar, Robert L, Piedra, Pedro A, Couch, Robert B
• Format: Journal Article
• Language: English
• Published: Chicago, IL American Medical Association 26.01.2000
• Subjects: Acute Disease; Adolescent; Adult; Aged; Biological and medical sciences; Child; Child, Preschool; Chronic Disease; Disease Susceptibility; Hospitalization; Hospitalization - statistics & numerical data; Human viral diseases; Humans; Infant; Infections; Infectious diseases; Influenza, Human - epidemiology; Medical sciences; Middle Aged; Paramyxoviridae Infections - epidemiology; Respiratory diseases; Respiratory Syncytial Virus Infections - epidemiology; Respiratory Tract Infections - epidemiology; Respiratory Tract Infections - virology; Risk Factors; Socioeconomic Factors; Viral diseases; Viral diseases of the respiratory system and ent viral diseases; Viruses; Human; Evaluation; Respiratory disease; Acute; Virological exploration; Etiopathogenesis; Vulnerability; Respiratory system; Epidemiology; Incidence; Infection; Public health organization; Viral disease; Public health; Socioeconomic inquiry
• ISSN: 0098-7484; 1538-3598
• DOI: 10.1001/jama.283.4.499

CONTEXT While hospitalization rates have declined overall, hospitalizations for acute lower respiratory tract infections have increased steadily since 1980. Development of new approaches for prevention of acute respiratory tract conditions requires studies of the etiologies of infections and quantification of the risk of hospitalization for vulnerable patients. OBJECTIVE To determine the frequency of specific virus infections associated with acute respiratory tract conditions leading to hospitalization of chronically ill patients. DESIGN Analysis of viral etiology of patients hospitalized with acute respiratory tract conditions between July 1991 and June 1995. SETTING Four large clinics and related hospitals serving diverse populations representative of Harris County, Texas. PATIENTS A total of 1029 patients who were hospitalized for pneumonia, tracheobronchitis, bronchiolitis, croup, exacerbations of asthma or chronic obstructive pulmonary disease, and/or congestive heart failure. MAIN OUTCOME MEASURE Virus infection, defined by culture, antigen detection, and significant rise in serum antibodies, by underlying condition; hospitalization rates by low- vs middle-income status. RESULTS Ninety-three percent of patients older than 5 years had a chronic underlying condition; a chronic pulmonary condition was most common. Patients with chronic pulmonary disease from low-income populations were hospitalized at a rate of 398.6 per 10,000, almost 8 times higher than the rate for patients from middle-income groups (52.2 per 10,000; P<.001). Of the 403 patients (44.4% of adults and 32.3% of children) who submitted convalescent serum specimens for antibody testing, respiratory tract virus infections were detected in 181 (44.9%). Influenza, parainfluenza, and respiratory syncytial virus (RSV) infections accounted for 75% of all virus infections. CONCLUSIONS Our study suggests that respiratory virus infections commonly trigger serious acute respiratory conditions that result in hospitalization of patients with chronic underlying conditions, highlighting the need for development of effective vaccines for these viruses, especially for parainfluenza and RSV.