Prolongation of the P-300 Latency Associated With Hydrogen Sulfide Exposure

• Three patients exposed to hydrogen sulfide developed persistent cognitive impairment, as suggested by the P-300 event-related potential and measured by neuropsychological testing. Routine neurological and physical examinations were unremarkable, although the patients were sufficiently impaired so...

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Published inArchives of neurology (Chicago) Vol. 46; no. 8; pp. 902 - 904
Main Authors Wasch, Heidi H, Estrin, William J, Yip, Peter, Bowler, Rosemarie, Cone, James E
Format Journal Article
LanguageEnglish
Published Chicago, IL American Medical Association 01.08.1989
Subjects
Accidents, Occupational
Adult
Biological and medical sciences
Brain - drug effects
Brain - physiopathology
Chemical and industrial products toxicology. Toxic occupational diseases
Evoked Potentials, Auditory
Gas, fumes
Humans
Hydrogen Sulfide - poisoning
Male
Medical sciences
Neurologic Examination
Neuropsychological Tests
Toxicology
Human
Gases
Nervous system diseases
Hydrogen Sulfides
Acquisition process
Cognitive disorder
Toxicity
Electrophysiology
Action potential
Occupational exposure
Neuropsychologia
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Summary:• Three patients exposed to hydrogen sulfide developed persistent cognitive impairment, as suggested by the P-300 event-related potential and measured by neuropsychological testing. Routine neurological and physical examinations were unremarkable, although the patients were sufficiently impaired so as to be unable to work. The P-300 event-related potential and neuropsychological testing proved to be important in the detection of cognitive dysfunction following acute hydrogen sulfide exposure. The three patients with neurocognitive dysfunction were acutely exposed to hydrogen sulfide. The incidents occurred independently and under different circumstances. Each patient was evaluated at the Northern California Occupational Health Clinic, San Francisco, examined neurologically and neuropsychologically, and evaluated with a P-300 event-related potential. Each patient had persistent neurological symptoms, neuropsychological deficit, and abnormally prolonged P-300 latencies.
ISSN:0003-9942
1538-3687
DOI:10.1001/archneur.1989.00520440096025