Effect of ketamine on the stapedius reflex in the squirrel monkey

We evaluated the effect of ketamine hydrochloride on the acoustically elicited stapedius reflex of squirrel monkeys. After intramuscular injection, in the presence of normal tympanometry, the amplitude of the contralateral stapedius reflex was severely depressed, even at low, preanesthetic dose leve...

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Bibliographic Details
Published inArchives of otolaryngology (1960) Vol. 110; no. 1; p. 22
Main Authors Thompson, G C, Stach, B A, Jerger, J F
Format Journal Article
LanguageEnglish
Published United States 01.01.1984
Subjects
Acoustic Impedance Tests
Animals
Ketamine - pharmacology
Pentobarbital - pharmacology
Reflex, Acoustic - drug effects
Saimiri
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Summary:We evaluated the effect of ketamine hydrochloride on the acoustically elicited stapedius reflex of squirrel monkeys. After intramuscular injection, in the presence of normal tympanometry, the amplitude of the contralateral stapedius reflex was severely depressed, even at low, preanesthetic dose levels. Possible mechanisms for the mediation of this unexpected effect are discussed.
ISSN:0003-9977
DOI:10.1001/archotol.1984.00800270026007