New Bioactive Metabolites from a Freshwater Isolate of the Fungus Kirschsteiniothelia sp

• Published in: Journal of natural products (Washington, D.C.) Vol. 55; no. 8; pp. 1093 - 1099
• Main Authors: Poch, Gregory K, Gloer, James B, Shearer, Carol A
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.08.1992; Glendale, AZ American Society of Pharmacognosy
• Subjects: Anti-Bacterial Agents; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - pharmacology; Ascomycota - chemistry; Ascomycota - metabolism; Bacillus subtilis - drug effects; Biological and medical sciences; General pharmacology; Magnetic Resonance Spectroscopy; Medical sciences; Microbial Sensitivity Tests; Naphthoquinones - isolation & purification; Naphthoquinones - pharmacology; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Staphylococcus aureus - drug effects; Fungi; Molecular structure; Fresh water; Isolate; Isolation; Naphthoquinone derivatives; Antibacterial agent; Mycelium; Thallophyta
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np50086a010

The new cytotoxic naphthoquinone dimer kirschsteinin [5], two new chlorinated diphenyl ethers 8 and 9, three known naphthoquinone derivatives 1, 2, and 7, a monoacetyl derivative of 2, and the (-)-enantiomer of O-methylasparvenone [4], have been isolated from a previously undescribed species of Kirschsteiniothelia. The structures of these compounds were assigned primarily by nmr studies and by spectral comparisons.