Electrospun PVP-Core/PHBV-Shell Fibers to Eliminate Tailing Off for an Improved Sustained Release of Curcumin

• Published in: Molecular pharmaceutics Vol. 18; no. 11; pp. 4170 - 4178
• Main Authors: Liu, Yubo, Chen, Xiaohong, Yu, Deng-Guang, Liu, Hang, Liu, Yuyang, Liu, Ping
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 01.11.2021
• Subjects: Curcumin - administration & dosage; Curcumin - pharmacokinetics; Delayed-Action Preparations - administration & dosage; Delayed-Action Preparations - pharmacokinetics; Drug Compounding - methods; Drug Liberation; Nanoparticle Drug Delivery System - chemistry; Polyesters - chemistry; Povidone - chemistry; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction; core−shell fibers; sustained release; molecules; curcumin; poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
• ISSN: 1543-8384; 1543-8392; 1543-8392
• DOI: 10.1021/acs.molpharmaceut.1c00559

Tailing off release in the sustained release of water-insoluble curcumin (Cur) is a significant challenge in the drug delivery system. As a novel solution, core–shell nanodrug containers have aroused many interests due to their potential improvement in drug-sustained release. In this work, a biodegradable polymer, poly­(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), and hydrophilic polyvinylpyrrolidone (PVP) were exploited as drug delivery carriers by coaxial electrospinning, and the core–shell drug-loaded fibers exhibited improved sustained release of Cur. A cylindrical morphology and a clear core–shell structure were observed by scanning and transmission electron microscopies. The X-ray diffraction pattern and infrared spectroscopy revealed that Cur existed in amorphous form due to its good compatibility with PHBV and PVP. The in vitro drug release curves confirmed that the core–shell container manipulated Cur in a faster drug release process than that in the traditional PHBV monolithic container. The combination of the material and structure forms a novel nanodrug container with a better sustained release of water-insoluble Cur. This strategy is beneficial for exploiting more functional biomedical materials to improve the drug release behavior.