Multi-Arm Star-Shaped Glycopolymers with Precisely Controlled Core Size and Arm Length

Star-shaped glycopolymers provide very high binding activities toward lectins. However, a straightforward synthesis method for the preparation of multi-arm glycopolymers in a one-pot approach has been challenging. Herein, we report a rapid synthesis of well-defined multi-arm glycopolymers via Cu(0)-...

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Published inBiomacromolecules Vol. 21; no. 9; pp. 3736 - 3744
Main Authors Monaco, Alessandra, Beyer, Valentin P, Napier, Richard, Becer, C. Remzi
Format Journal Article
LanguageEnglish
Published American Chemical Society 14.09.2020
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Summary:Star-shaped glycopolymers provide very high binding activities toward lectins. However, a straightforward synthesis method for the preparation of multi-arm glycopolymers in a one-pot approach has been challenging. Herein, we report a rapid synthesis of well-defined multi-arm glycopolymers via Cu(0)-mediated reversible deactivation radical polymerization in aqueous media. d-Mannose acrylamide has been homo- and copolymerized with NIPAM to provide linear arms and then core cross-linked with a bisacrylamide monomer. Thus, the arm length and core size of multi-arm glycopolymers were tuned. Moreover, the stability of multi-arm glycopolymers was investigated, and degradation reactions under acidic or basic conditions were observed. The binding activities of the obtained multi-arm glycopolymers with mannose-specific human lectins, DC-SIGN and MBL, were investigated via surface plasmon resonance spectroscopy. Finally, the encapsulation ability of multi-arm glycopolymers was examined using DHA and Saquinavir below and above the lower critical solution temperature (LCST) of P­(NIPAM).
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ISSN:1525-7797
1526-4602
DOI:10.1021/acs.biomac.0c00838