The impact of cranial irradiation on the growth of children with acute lymphocytic leukemia

Heights, height velocities, weights, and weight velocities were measured serially in 21 patients with acute lymphocytic leukemia (ALL) who had survived three to five years in continuous complete remission. These patients were assigned randomly to treatment regimens that varied according to whether c...

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Bibliographic Details
Published inAmerican journal of diseases of children (1960) Vol. 137; no. 1; p. 37
Main Authors Wells, R J, Foster, M B, D'Ercole, A J, McMillan, C W
Format Journal Article
LanguageEnglish
Published United States 01.01.1983
Subjects
Body Height - radiation effects
Body Weight - radiation effects
Child
Child, Preschool
Clinical Trials as Topic
Female
Growth - radiation effects
Humans
Infant
Leukemia, Lymphoid - radiotherapy
Male
Random Allocation
Skull - radiation effects
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Summary:Heights, height velocities, weights, and weight velocities were measured serially in 21 patients with acute lymphocytic leukemia (ALL) who had survived three to five years in continuous complete remission. These patients were assigned randomly to treatment regimens that varied according to whether cranial irradiation was used. Patients receiving cranial irradiation had lower height velocities during therapy than normal subjects and patients not receiving cranial irradiation. Twenty-two other children with ALL, who were irradiated but not randomized, exhibited similar alterations in growth. These results indicate that cranial irradiation, and not leukemia or antileukemia chemotherapy, causes reduced growth.
ISSN:0002-922X
DOI:10.1001/archpedi.1983.02140270033012