Peptide Supramolecular Hydrogels with Sustained Release Ability for Combating Multidrug-Resistant Bacteria

• Published in: ACS applied materials & interfaces Vol. 15; no. 22; pp. 26273 - 26284
• Main Authors: Shang, Lu, Liu, Jing, Wu, Yuting, Wang, Mi, Fei, Chenzhong, Liu, Yingchun, Xue, Feiqun, Zhang, Lifang, Gu, Feng
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 07.06.2023
• Subjects: Animals; Anti-Bacterial Agents - chemistry; antimicrobial peptides; antimicrobial properties; arginine; biocompatible materials; biofilm; Biological and Medical Applications of Materials and Interfaces; cell proliferation; collagen; crosslinking; Delayed-Action Preparations - pharmacology; drugs; hydrogels; Hydrogels - chemistry; inflammation; Methicillin-Resistant Staphylococcus aureus; Mice; mortality; multiple drug resistance; muscles; nanofibers; Peptides - pharmacology; Peptides - therapeutic use; therapeutics; Wound Infection - drug therapy; chronic wound healing; antimicrobial hydrogel; arginine end-tagging peptides; supramolecular biomaterial; sustained release

Chronic wound infection caused by multidrug-resistant bacteria is a major threat globally, leading to high mortality rates and a considerable economic burden. To address it, an innovative supramolecular nanofiber hydrogel (Hydrogel-RL) harboring antimicrobial peptides was developed based on the nove...