Electrospun Mucoadhesive Zein/PVP Fibroporous Membrane for Transepithelial Delivery of Propranolol Hydrochloride

• Published in: Molecular pharmaceutics Vol. 20; no. 1; pp. 508 - 523
• Main Authors: Surendranath, Medha, Ramesan, Rekha M., Nair, Prakash, Parameswaran, Ramesh
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 02.01.2023
• Subjects: Animals; Drug Delivery Systems - methods; Mouth Mucosa; Povidone; Propranolol - pharmacology; Swine; Zein - chemistry; Zein - metabolism; Zein - pharmacology; zein; mucoadhesive drug delivery; PVP; electrospinning; propranolol hydrochloride

Mucoadhesive drug delivery systems have been extensively studied to effectively reduce the limitations of conventional drug delivery systems. Zein and polyvinyl pyrrolidone (PVP) are appraised for mucoadhesive properties. This study focuses on developing a mechanically stable zein/PVP electrospun me...