Electrospun Mucoadhesive Zein/PVP Fibroporous Membrane for Transepithelial Delivery of Propranolol Hydrochloride

Mucoadhesive drug delivery systems have been extensively studied to effectively reduce the limitations of conventional drug delivery systems. Zein and polyvinyl pyrrolidone (PVP) are appraised for mucoadhesive properties. This study focuses on developing a mechanically stable zein/PVP electrospun me...

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Published inMolecular pharmaceutics Vol. 20; no. 1; pp. 508 - 523
Main Authors Surendranath, Medha, Ramesan, Rekha M., Nair, Prakash, Parameswaran, Ramesh
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 02.01.2023
Subjects
Animals
Drug Delivery Systems - methods
Mouth Mucosa
Povidone
Propranolol - pharmacology
Swine
Zein - chemistry
Zein - metabolism
Zein - pharmacology
zein
mucoadhesive drug delivery
PVP
electrospinning
propranolol hydrochloride
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Summary:Mucoadhesive drug delivery systems have been extensively studied to effectively reduce the limitations of conventional drug delivery systems. Zein and polyvinyl pyrrolidone (PVP) are appraised for mucoadhesive properties. This study focuses on developing a mechanically stable zein/PVP electrospun membrane for propranolol hydrochloride (PL) transport. Fourier transform infrared, Raman spectra, and swelling studies gave evidence for PVP crosslinking, whereas circular dichroism spectroscopy revealed crosslinking of zein owing to the conformational change from α-helix to β-sheet. A 10 h thermal treatment of zein/PVP imparted 3.92 ± 0.13 MPa tensile strength to the matrix. Thermally crosslinked electrospun zein/PVP matrix showed 22.1 ± 0.1 g mm work of adhesion in porcine buccal mucosa tissue. Qualitative and quantitative evaluation of cytotoxicity in RPMI 2650 has been carried out. The in vitro drug release profile of PL from thermally crosslinked zein/PVP best fitted with the Korsmeyer–Peppas model. Immunostaining of β-catenin adherens junctional protein confirmed the absence of paracellular transport through the junctional opening. Still, drug permeation was observed through the porcine buccal mucosa, attributed to the transcellular transport of PL owing to its lipophilicity. The ex vivo permeation of PL through porcine buccal mucosa was also evaluated.
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ISSN:1543-8384
1543-8392
DOI:10.1021/acs.molpharmaceut.2c00746