Methoxymethylation of Alcohols, Phenols, and Avermectin Aglycones Using MOM-2-pyridylsulfide

Methoxymethyl-2-pyridylsulfide (MOM-ON) is an effective methoxymethylating reagent when used in conjunction with AgOTf, NaOAc, and THF. A wide range of MOM ethers are produced from corresponding phenols and alcohols, including tertiary and allylic alcohols, in good yields and under mild, neutral con...

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Bibliographic Details
Published inJournal of organic chemistry Vol. 64; no. 7; pp. 2446 - 2449
Main Authors Marcune, Benjamin F, Karady, Sandor, Dolling, Ulf-H, Novak, Thomas J
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 02.04.1999
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ETHERS
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Summary:Methoxymethyl-2-pyridylsulfide (MOM-ON) is an effective methoxymethylating reagent when used in conjunction with AgOTf, NaOAc, and THF. A wide range of MOM ethers are produced from corresponding phenols and alcohols, including tertiary and allylic alcohols, in good yields and under mild, neutral conditions. This method is also effective for the methoxymethylation of avermectin aglycones.
Bibliography:istex:3C299D108FF884499DD0B2359F5F7A318F50F63C
ark:/67375/TPS-8MPHSG3J-F
ISSN:0022-3263
1520-6904
DOI:10.1021/jo9822582