Metal–Organic Framework@Porous Organic Polymer Nanocomposite for Photodynamic Therapy

The limitation for the biomedical application of porous organic polymers (POPs) is the big size and poor dispersibility in aqueous media. Herein, a nanoscale metal–organic framework (MOF)@POP composite, named UNM, has been synthesized by epitaxial growth of the photoactive porphyrin-POPs (H2P-POP) o...

Full description

Saved in:
Bibliographic Details
Published inChemistry of materials Vol. 29; no. 5; pp. 2374 - 2381
Main Authors Zheng, Xiaohua, Wang, Lei, Pei, Qing, He, Shasha, Liu, Shi, Xie, Zhigang
Format Journal Article
LanguageEnglish
Published American Chemical Society 14.03.2017
Online AccessGet full text

Cover

More Information
Summary:The limitation for the biomedical application of porous organic polymers (POPs) is the big size and poor dispersibility in aqueous media. Herein, a nanoscale metal–organic framework (MOF)@POP composite, named UNM, has been synthesized by epitaxial growth of the photoactive porphyrin-POPs (H2P-POP) on the outer surface of amine containing UiO-66 (UiO-AM). After the growth of POPs, the crystallization, pore structure, and size distribution of UNM are retained well. The formed UNM possesses a small size of less than 200 nm and could be internalized by cancer cells. Such light-activated UNM exhibits efficient ability to generate 1O2 under various experimental conditions, which can be further applied for PDT efficacy. The present work demonstrates the great potential of nanoscale porous polymers in biomedical fields and cancer treatment.
ISSN:0897-4756
1520-5002
DOI:10.1021/acs.chemmater.7b00228