Pd-Catalyzed Asymmetric C–H Bond Activation for the Synthesis of P‑Stereogenic Dibenzophospholes

Pd-catalyzed asymmetric C–H bond activation for the synthesis of P-stereogenic dibenzophospholes was efficiently achieved via two types of catalytic systems. Chiral phosphoric amides/acids as ligands provided the products with up to 5:95 er, and (R)-segphos as ligand resulted in enantioselectivities...

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Bibliographic Details
Published inOrganometallics Vol. 38; no. 20; pp. 3916 - 3920
Main Authors Li, Zhen, Lin, Zi-Qi, Yan, Chao-Guo, Duan, Wei-Liang
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 28.10.2019
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Physical Sciences
Science & Technology
BRONSTED ACID
FUNCTIONALIZATION
PHOSPHATE
C(SP)-H BONDS
ENANTIOSELECTIVE SYNTHESIS
MECHANISM
PHOSPHORIC-ACID
PHOSPHINES
ARYLATION
INDOLINES
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Summary:Pd-catalyzed asymmetric C–H bond activation for the synthesis of P-stereogenic dibenzophospholes was efficiently achieved via two types of catalytic systems. Chiral phosphoric amides/acids as ligands provided the products with up to 5:95 er, and (R)-segphos as ligand resulted in enantioselectivities of up to 98:2.
ISSN:0276-7333
1520-6041
DOI:10.1021/acs.organomet.9b00216