Graphdiyne Materials as Nanotransducer for in Vivo Photoacoustic Imaging and Photothermal Therapy of Tumor

• Published in: Chemistry of materials Vol. 29; no. 14; pp. 6087 - 6094
• Main Authors: Li, Shengliang, Chen, Yanhuan, Liu, Huibiao, Wang, Yunxia, Liu, Libing, Lv, Fengting, Li, Yuliang, Wang, Shu
• Format: Journal Article
• Language: English
• Published: American Chemical Society 25.07.2017
• ISSN: 0897-4756; 1520-5002
• DOI: 10.1021/acs.chemmater.7b01965

Two-dimensional (2D) all-carbon materials hold great fascination because of their superior properties and promising applications. Herein, we presented the first demonstration for the use of graphdiyne (GDY) as photothermo-acoustic wave nanotransducers for simultaneous effective photoacoustic imaging (PAI) and photothermal therapy (PTT) in living mice. With a large extinction coefficient in near-infrared (NIR) region, upon irradiated by 808 nm laser, GDY not only exhibits a stable photothermal performance with a high photothermal conversion efficiency of 42%, but also provides an excellent photoacoustic response. Owing to its good biocompatibility modified with PEGylation, GDY can be simultaneously used as PAI probe and PTT agent and exhibits an efficient photothermal ablation of cancer cells in living mice. This work opens a new way into the development of 2D graphdiynes as novel theranostic platform for cancer treatment.