Synthesis of Multifunctional Polymers through the Ugi Reaction for Protein Conjugation

The Ugi reaction has been utilized as a multicomponent click reaction to efficiently synthesize a series of multifunctional PEGylation agents, and those PEG derivatives were successfully conjugated on a protein surface to generate corresponding multifunctional protein–polymer conjugates, indicating...

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Bibliographic Details
Published inMacromolecules Vol. 47; no. 16; pp. 5607 - 5612
Main Authors Yang, Bin, Zhao, Yuan, Wang, Shiqi, Zhang, Yaling, Fu, Changkui, Wei, Yen, Tao, Lei
Format Journal Article
LanguageEnglish
Published American Chemical Society 26.08.2014
Subjects
chemical derivatives
chemical reactions
polymers
synthesis
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Summary:The Ugi reaction has been utilized as a multicomponent click reaction to efficiently synthesize a series of multifunctional PEGylation agents, and those PEG derivatives were successfully conjugated on a protein surface to generate corresponding multifunctional protein–polymer conjugates, indicating the promising potential of the Ugi reaction in the field of PEGylation.
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ISSN:0024-9297
1520-5835
1520-5835
DOI:10.1021/ma501385m