Microporous Coatings of PEKK/SN Composites Integration with PEKK Exhibiting Antibacterial and Osteogenic Activity, and Promotion of Osseointegration for Bone Substitutes

• Published in: ACS biomaterials science & engineering Vol. 5; no. 3; pp. 1290 - 1301
• Main Authors: Wu, Han, Yang, Lili, Qian, Jun, Wang, Deqing, Pan, Yongkang, Wang, Xuehong, Nabanita, Saha, Tang, Tingting, Zhao, Jun, Wei, Jie
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 11.03.2019
• Subjects: antibacterial activity; poly(etherketoneketone); microporous coating; silicon nitride; osteogenic activity
• ISSN: 2373-9878; 2373-9878
• DOI: 10.1021/acsbiomaterials.8b01508

To improve the antibacterial and osteogenic activities of poly­(etherketoneketone) (PEKK), concentrated sulfuric acid (H2SO4) suspension with silicon nitride (SN) microparticle was utilized to modify PEKK surface. Through sulfonation reaction, microporous coatings of PEKK/SN composites were created on PEKK surface, which were integrated with PEKK substrate. The results showed that the content of SN in the microporous coatings increased with the increase of SN content in H2SO4 suspension (PKS without SN, PKSC5 and PKSC10 with 5 and 10 wt % SN content in H2SO4) and that the surface roughness and hydrophilicity of microporous coatings on PEKK were significantly improved with the SN content increasing. In addition, the microporous coating of PKSC10 with high SN content exhibited excellent antibacterial activity due to the synergistic action of the presence of amino (−NH2) and sulfonic acid (−SO3H) groups as well as the improvement of protein absorption. Moreover, the microporous coating of PKSC10 obviously stimulated adhesion, proliferation, and osteogenic differentiation of rat bone mesenchymal stem cells. Furthermore, histological and push-out load evaluation indicated that the microporous coating of PKSC10 significantly promoted osteogenesis and osseointegration in vivo. The results suggested that the microporous coating of PKSC10 with high SN content display good biocompatibility, antibacterial and osteogenic activities, and osseointegration ability, which would have great potential for bone substitutes.