Regioselective Transition-Metal-Free Oxidative Cyclobutanol Ring Expansion to 4‑Tetralones
A facile and transition-metal-free ring expansion of the cyclobutanol moiety to 4-tetralones fused to heteroaromatic systems is described. The oxidative ring expansion proceeds rapidly and regioselectively through mediation by N-bromosuccinimide and acetonitrile in satisfactory to good yields. The p...
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Published in | Organic letters Vol. 20; no. 24; pp. 8030 - 8034 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
21.12.2018
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
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Summary: | A facile and transition-metal-free ring expansion of the cyclobutanol moiety to 4-tetralones fused to heteroaromatic systems is described. The oxidative ring expansion proceeds rapidly and regioselectively through mediation by N-bromosuccinimide and acetonitrile in satisfactory to good yields. The preparation of precursors and the ring expansion have proven to be scalable and are straightforward to carry out. |
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Bibliography: | UKRI |
ISSN: | 1523-7060 1523-7052 |
DOI: | 10.1021/acs.orglett.8b03619 |