DNA Redox Hydrogels: Improving Mediated Enzymatic Bioelectrocatalysis

We present the preparation of a redox DNA hydrogel for mediated bioelectrocatalysis of oxidoreductase enzymes for biosensor and biofuel cell applications. The noncovalent functionalization of DNA with redox molecules is achieved by intercalation of aromatic redox probes into the DNA double helix or...

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Bibliographic Details
Published inACS catalysis Vol. 6; no. 4; pp. 2603 - 2607
Main Authors Nguyen, Khiem Van, Holade, Yaovi, Minteer, Shelley D
Format Journal Article
LanguageEnglish
Published American Chemical Society 01.04.2016
Subjects
Chemical Sciences
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Summary:We present the preparation of a redox DNA hydrogel for mediated bioelectrocatalysis of oxidoreductase enzymes for biosensor and biofuel cell applications. The noncovalent functionalization of DNA with redox molecules is achieved by intercalation of aromatic redox probes into the DNA double helix or electrostatic binding of redox-active tetraalkylammonium ions to phosphate groups on DNA. Prepared DNA redox hydrogels demonstrate the capability of mediating bioelectrocatalytic glucose oxidation by oxidoreductase enzymes. This is the first evidence that redox DNA hydrogels can replace redox polymer hydrogels for self-exchange-based mediation for bioelectrocatalytic applications. This study contributes toward advances in the use of DNA, an emerging biomaterial, in enzymatic bioelectrocatalysis-based applications.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.5b02699