Simultaneous Reduction and Surface Functionalization of Graphene Oxide for Hydroxyapatite Mineralization

• Published in: Journal of physical chemistry. C Vol. 116; no. 5; pp. 3334 - 3341
• Main Authors: Liu, Hongyan, Xi, Pinxian, Xie, Guoqiang, Shi, Yanjun, Hou, Fengping, Huang, Liang, Chen, Fengjuan, Zeng, Zhengzhi, Shao, Changwei, Wang, Jun
• Format: Journal Article
• Language: English
• Published: Columbus, OH American Chemical Society 09.02.2012
• Subjects: Cross-disciplinary physics: materials science; rheology; Exact sciences and technology; Fullerenes and related materials; diamonds, graphite; Materials science; Nanocrystalline materials; Nanoscale materials and structures: fabrication and characterization; Physics; Specific materials; Dopamine; Hybrid material; Hydroxyapatite; Minerals; Nanoparticles; Body fluids; Composite materials; Biomimetics; Functionalization; Nanocomposites; Graphene; Mineralization; Fibroblasts; Oxidative polymerization; Nanostructured materials
• ISSN: 1932-7447; 1932-7455
• DOI: 10.1021/jp2102226

In this study, we present the synthesis of reduced graphene oxide/hydroxyapatite (RGO/HA) hybrid materials by an environmental-friendly route. Graphene oxide (GO) was first simultaneously reduced and surface functionalized by one-step oxidative polymerization of dopamine (PDA). The bioinspired surface was further used for biomimetic mineralization of hydroxyapatite. When incubated in a simulated body fluid (SBF), the PDA layer enabled efficient interaction between the RGO surface and the mineral ions to improve the bioactivity, promoted the formation of the HA nanoparticles. A detailed structural and morphological characterization of the mineralized composite was performed. The HA-based hybrid materials exhibited no cytotoxic effect on L929 fibroblast cells, showing potential capacity of being a scaffold material for bone tissue regeneration and implantation. This facile strategy also can be a useful platform for other RGO-based nanocomposites.