Antitumor Agents, 110, Bryophyllin B, a Novel Potent Cytotoxic Bufadienolide from Bryophyllum pinnatum

Bryophyllin B [1], a potent cytotoxic bufadienolide, has been isolated from Bryophyllum pinnatum and its structure confirmed by the use of 2D-nmr techniques and difference nOe method. Transformation of bryotoxin C [2] to 1 with acid is also discussed.

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Bibliographic Details
Published inJournal of natural products (Washington, D.C.) Vol. 52; no. 5; pp. 1071 - 1079
Main Authors Yamagishi, Takashi, Haruna, Mitsumasa, Yan, Xiu-Zhen, Chang, Jer-Jang, Lee, Kuo-Hsiung
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.09.1989
Subjects
AGENTES ANTINEOPLASTICOS
ANTINEOPLASTIC AGENTS
Antineoplastic Agents, Phytogenic - isolation & purification
Bufanolides - isolation & purification
Bufanolides - pharmacology
CRASSULACEAE
Drug Screening Assays, Antitumor
Magnetic Resonance Spectroscopy
MEDICAMENT CYTOSTATIQUE
Molecular Structure
Plants - analysis
TOXICIDAD
TOXICITE
TOXICITY
Tumor Cells, Cultured
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Summary:Bryophyllin B [1], a potent cytotoxic bufadienolide, has been isolated from Bryophyllum pinnatum and its structure confirmed by the use of 2D-nmr techniques and difference nOe method. Transformation of bryotoxin C [2] to 1 with acid is also discussed.
Bibliography:F60
Q60
9018629
istex:6B41CBE750968B93B16288D03410919186036249
ark:/67375/TPS-36L4BGNM-4
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0163-3864
1520-6025
DOI:10.1021/np50065a025