Synthesis, absorption, and toxicity of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator

• Published in: Journal of medicinal chemistry Vol. 23; no. 10; pp. 1130 - 1133
• Main Authors: Bergeron, Raymond J, Burton, Philip S, McGovern, Kathy Ann, St. Onge, Erica J, Streiff, Richard R
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 01.10.1980
• Subjects: Animals; In Vitro Techniques; Intestinal Absorption; Iron Chelating Agents - chemical synthesis; Iron Chelating Agents - metabolism; Iron Chelating Agents - toxicity; Mice; Spermidine - analogs & derivatives; Spermidine - chemical synthesis; Spermidine - metabolism; Spermidine - toxicity

A synthesis of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator, is developed employing N4-benzylspermidine as the starting material. Both the toxicity and the absorption properties of this compound are evaluated, further supporting its potential as a clinical iron chelator.