Synthesis, absorption, and toxicity of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator
A synthesis of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator, is developed employing N4-benzylspermidine as the starting material. Both the toxicity and the absorption properties of this compound are evaluated, further supporting its potential as a clinical iron chelator.
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Published in | Journal of medicinal chemistry Vol. 23; no. 10; pp. 1130 - 1133 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Chemical Society
01.10.1980
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Subjects | |
Online Access | Get full text |
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Summary: | A synthesis of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator, is developed employing N4-benzylspermidine as the starting material. Both the toxicity and the absorption properties of this compound are evaluated, further supporting its potential as a clinical iron chelator. |
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Bibliography: | istex:E87355FBEFE707D324FAF18E4FB44DF80E66FC7E ark:/67375/TPS-Q6WN2FG2-J |
ISSN: | 0022-2623 1520-4804 |
DOI: | 10.1021/jm00184a013 |