Synthesis and antibacterial activity of 2'-substituted chelocardin analogs

Chelocardin (1) was condensed with numerous hydrazines, hydrazides, and anilines, yielding 2'-substituted derivatives with antibacterial spectra similar to the parent antibiotic. The hydrazone derivatives 9 and 10 and the two anilino derivatives 42 and 44 had more in vivo antibacterial activity...

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Bibliographic Details
Published inJournal of medicinal chemistry Vol. 22; no. 5; pp. 559 - 564
Main Authors Garmaise, David L, Chu, Daniel T. W, Bernstein, Edith, Inaba, Makoto
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.05.1979
Subjects
Animals
Methods
Mice
Microbial Sensitivity Tests
Proteus Infections - drug therapy
Proteus mirabilis
Proteus vulgaris - drug effects
Proteus vulgaris - growth & development
Tetracyclines - chemical synthesis
Tetracyclines - pharmacology
Tetracyclines - therapeutic use
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Summary:Chelocardin (1) was condensed with numerous hydrazines, hydrazides, and anilines, yielding 2'-substituted derivatives with antibacterial spectra similar to the parent antibiotic. The hydrazone derivatives 9 and 10 and the two anilino derivatives 42 and 44 had more in vivo antibacterial activity than chelocardin.
Bibliography:istex:96CE013FE85D20910A0A4E4DB7D724920438D0E9
ark:/67375/TPS-8MGDSB6K-T
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00191a018