Visualization of Boronic Acid Containing Pharmaceuticals in Live Tumor Cells Using a Fluorescent Boronic Acid Sensor

Boronic acid containing compounds are regarded as a new class of pharmaceuticals, and the distribution in live cells is crucial for the development of novel drugs. However, generic detection methods for boron compounds are not suitable for live-cell imaging, and the fluorescence-labeling technique i...

Full description

Saved in:
Bibliographic Details
Published inACS sensors Vol. 1; no. 12; pp. 1394 - 1397
Main Authors Hattori, Yoshihide, Ishimura, Miki, Ohta, Yoichiro, Takenaka, Hiroshi, Kirihata, Mitsunori
Format Journal Article
LanguageEnglish
Published American Chemical Society 23.12.2016
Subjects
tavaborole
p-boronophenylalanine
boron-based pharmaceuticals
fluorescent boronic acid sensor
live-cell imaging
molecular probe
Online AccessGet full text

Cover

More Information
Summary:Boronic acid containing compounds are regarded as a new class of pharmaceuticals, and the distribution in live cells is crucial for the development of novel drugs. However, generic detection methods for boron compounds are not suitable for live-cell imaging, and the fluorescence-labeling technique is challenging to apply for small molecules. Fluorescent boron-sensor DAHMI which is based on a boron chelating ligand was developed for a novel visualization method of boron-based pharmaceuticals in the live cell. In this study, we analyzed the distribution of boronic acid derivatives in live cells using a fluorescent boronic acid sensor.
ISSN:2379-3694
2379-3694
DOI:10.1021/acssensors.6b00522