Neuroendocrine abnormalities in bulimia

The authors examined the relationship of clinical variables, family history, and neuroendocrine function in 18 bulimic patients. Twelve of 18 patients (67%) showed abnormalities of cortisol suppression, and 8 of 10 (80%) showed blunted thyrotropin-releasing hormone (TRH) tests. These findings sugges...

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Bibliographic Details
Published inThe American journal of psychiatry Vol. 140; no. 5; p. 559
Main Authors Gwirtsman, H E, Roy-Byrne, P, Yager, J, Gerner, R H
Format Journal Article
LanguageEnglish
Published United States 01.05.1983
Subjects
Adolescent
Adult
Anorexia Nervosa - blood
Anorexia Nervosa - diagnosis
Dexamethasone
Feeding and Eating Disorders - diagnosis
Female
Humans
Hydrocortisone - blood
Hyperphagia - blood
Hyperphagia - complications
Hyperphagia - diagnosis
Mood Disorders - complications
Mood Disorders - diagnosis
Thyrotropin - blood
Thyrotropin-Releasing Hormone
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Summary:The authors examined the relationship of clinical variables, family history, and neuroendocrine function in 18 bulimic patients. Twelve of 18 patients (67%) showed abnormalities of cortisol suppression, and 8 of 10 (80%) showed blunted thyrotropin-releasing hormone (TRH) tests. These findings suggest that neuroendocrine abnormalities identified previously in anorexia nervosa are not solely an artifact of low weight and, further, that eating disorders and affective disorders may share neurochemical similarities.
ISSN:0002-953X
DOI:10.1176/ajp.140.5.559