Imparting Nanoparticle Function with Size-Controlled Amphiphilic Polymers

• Published in: Journal of the American Chemical Society Vol. 130; no. 12; pp. 3744 - 3745
• Main Authors: Chen, Yingchuan, Thakar, Rahul, Snee, Preston T
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 26.03.2008
• Subjects: Acrylic Resins - chemical synthesis; Acrylic Resins - chemistry; Cadmium Compounds - chemistry; Fluorescent Dyes - chemistry; Molecular Structure; Nanoparticles - chemistry; Particle Size; Selenium Compounds - chemistry; Sulfhydryl Compounds - chemical synthesis; Sulfhydryl Compounds - chemistry; Sulfides - chemistry; Surface Properties; Surface-Active Agents - chemical synthesis; Surface-Active Agents - chemistry; Zinc Compounds - chemistry
• ISSN: 0002-7863; 1520-5126
• DOI: 10.1021/ja711252n

Herein we report our method of water solubilization and subsequent functionalization of a variety of nanoparticle systems with amphiphilic polymers containing build-in “chemical handles”. We have used these polymers, which have narrow polydispersity indices, to impart water solubility and chemical sensitivity toward targeted species (here:  pH). These material systems have high chemical conjugation efficiencies in aqueous conditions which may be used to create a variety of chemical and biological multifunctional materials.