Porphyrin-Cored Polymer Nanoparticles: Macromolecular Models for Heme Iron Coordination

Porphyrin-cored polymer nanoparticles (PCPNs) were synthesized and characterized to investigate their utility as heme protein models. Created using collapsible heme-centered star polymers containing photodimerizable anthracene units, these systems afford model heme cofactors buried within hydrophobi...

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Published inInorganic chemistry Vol. 55; no. 19; pp. 9493 - 9496
Main Authors Rodriguez, Kyle J, Hanlon, Ashley M, Lyon, Christopher K, Cole, Justin P, Tuten, Bryan T, Tooley, Christian A, Berda, Erik B, Pazicni, Samuel
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 03.10.2016
Subjects
Coordination Complexes - chemical synthesis
Coordination Complexes - chemistry
Ferric Compounds - chemical synthesis
Ferric Compounds - chemistry
Heme - chemistry
Nanoparticles - chemistry
Polymers - chemical synthesis
Polymers - chemistry
Porphyrins - chemical synthesis
Porphyrins - chemistry
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Summary:Porphyrin-cored polymer nanoparticles (PCPNs) were synthesized and characterized to investigate their utility as heme protein models. Created using collapsible heme-centered star polymers containing photodimerizable anthracene units, these systems afford model heme cofactors buried within hydrophobic, macromolecular environments. Spectroscopic interrogations demonstrate that PCPNs display redox and ligand-binding reactivity similar to that of native systems and thus are potential candidates for modeling biological heme iron coordination.
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ISSN:0020-1669
1520-510X
DOI:10.1021/acs.inorgchem.6b01113