Mesojunction-Based Design Paradigm of Structural DNA Nanotechnology

Mesojunctions were introduced as a basic type of crossover configuration in the early development of structural DNA nanotechnology. However, the investigations of self-assembly from multiple mesojunction complexes have been overlooked in comparison to their counterparts based on regular junctions. I...

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Published inJournal of the American Chemical Society Vol. 145; no. 4; pp. 2455 - 2460
Main Authors Wang, Tianqi, Bai, Tanxi, Tan, Zhenyu, Ohayon, Yoel P., Sha, Ruojie, Vecchioni, Simon, Seeman, Nadrian C., Wei, Bryan
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.02.2023
American Chemical Society (ACS)
Subjects
Chemistry
DNA - chemistry
Nanostructures - chemistry
Nanotechnology - methods
Nucleic Acid Conformation
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Summary:Mesojunctions were introduced as a basic type of crossover configuration in the early development of structural DNA nanotechnology. However, the investigations of self-assembly from multiple mesojunction complexes have been overlooked in comparison to their counterparts based on regular junctions. In this work, we designed standardized component strands for the construction of complex mesojunction lattices. Three typical mesojunction configurations with three and four arms were showcased in the self-assembly of 1-, 2-, and 3-dimensional lattices constructed from both a scaffold-free tiling approach and a scaffolded origami approach.
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USDOE Office of Science (SC)
SC0007991
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.2c11731