Northalifoline, a New Isoquinolone Alkaloid from the Pedicels of Lindera megaphylla

• Published in: Journal of natural products (Washington, D.C.) Vol. 57; no. 6; pp. 689 - 694
• Main Authors: Chou, Cheng-Jen, Lin, Lie-Chwen, Chen, Kuo-Tung, Chen, Chieh-Fu
• Format: Journal Article
• Language: English
• Published: CINCINNATI American Chemical Society 01.06.1994; AMER SOC PHARMACOGNOSY; American Society of Pharmacognosy
• Subjects: ALCALOIDE; ALCALOIDE QUINOLIQUE; ALCALOIDES; ALCALOIDES DE LA QUINOLINA; ALKALOIDS; Biological and medical sciences; CHEMICAL COMPOSITION; Chemistry, Medicinal; COMPOSICION QUIMICA; COMPOSITION CHIMIQUE; ESPECTROMETRIA; General pharmacology; ISOQUINOLINE ALKALOIDS; LAURACEAE; Life Sciences & Biomedicine; Medical sciences; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PEDICELLE; PEDICELOS; PEDICELS; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; QUINOLINE ALKALOIDS; Science & Technology; SPECTRAL ANALYSIS; SPECTROMETRIE; SPECTROMETRY; TAIWAN; Alkaloid; Isoquinoline derivatives; Pharmacognosy; Dicotyledones; Angiospermae; Plant origin; Isolation; Spermatophyta; Lauraceae; Structural analysis; Medicinal plant
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np50108a001

A new isoquinolone alkaloid, northalifoline [1] was obtained from the pedicels of Lindera megaphylla along with six other alkaloids, namely, (+)-O-methylbulbocapnine [2], (+)-dicentrine [3], dicentrione [4], (+)-N-methylnandigerine [5], (+)-N-methylhernovine [6], and (+)-reticuline [7]. Characterization of northalifoline [1] by physical met hods and synthesis revealed its identity as 6-methoxy-7-hydroxy-1-oxo-1,2,3,4-tetrahydroisoquinoline.