Unraveling the Mystery Surrounding Cholesterol's Condensing Effect

The results of nearest-neighbor recognition experiments that have been carried out with exchangeable dimers derived from 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine, in the presence of cholesterol, dihydrocholesterol, coprostanol, cholestane,...

Full description

Saved in:
Bibliographic Details
Published inJournal of the American Chemical Society Vol. 125; no. 52; pp. 16182 - 16183
Main Authors Cao, Honghua, Tokutake, Nobuya, Regen, Steven L
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 31.12.2003
Subjects
Cholesterol - analogs & derivatives
Cholesterol - chemistry
Cholesterol - metabolism
Hydrogen Bonding
Hydrophobic and Hydrophilic Interactions
Kinetics
Lipid Bilayers - chemistry
Lipid Bilayers - metabolism
Phospholipids - chemistry
Phospholipids - metabolism
Sitosterols - chemistry
Sitosterols - metabolism
Structure-Activity Relationship
Online AccessGet full text

Cover

More Information
Summary:The results of nearest-neighbor recognition experiments that have been carried out with exchangeable dimers derived from 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine, in the presence of cholesterol, dihydrocholesterol, coprostanol, cholestane, cholesteryl methy ether, and sitosterol, provide strong support for a condensing mechanism in which the flexible acyl chains of the phospholipids complement, perfectly, the shape of neighboring sterols, thereby leading to a high number of hydrophobic contacts and tight packing.
Bibliography:istex:27CEE5AAC47F386B8153DC246F00C1B00A9B092E
ark:/67375/TPS-DS258VJR-7
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0002-7863
1520-5126
DOI:10.1021/ja039172x