Pathogen Receptor Membrane-Coating Facet Structures Boost Nanomaterial Immune Escape and Antibacterial Performance

• Published in: Nano letters Vol. 21; no. 23; pp. 9966 - 9975
• Main Authors: Hou, Xuan, Zeng, Hui, Chi, Xue, Hu, Xiangang
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 08.12.2021
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Humans; Hydrogen Peroxide; Nanostructures; Staphylococcal Infections - drug therapy; Staphylococcus aureus; pathogenic bacteria; nanomaterial; bionics; facet; cell membrane
• ISSN: 1530-6984; 1530-6992
• DOI: 10.1021/acs.nanolett.1c03427

Nanomaterials show great potential for the treatment of bacterial infections, but their effects remain limited by low antibacterial efficiency and immune clearance. Facet-dependent nanozymes coated with pathogen receptor membranes were fabricated, providing an approach for producing superphotothermal antibacterial nanomaterials with high biocompatibility and low immune clearance. (100)- and (112)-Faceted CuFeSe2 presented excellent photothermal conversion efficiency (46%). However, the peroxidase-like activity of (100)-faceted CuFeSe2 enhanced the decomposition of H2O2 to hydroxyl radicals (•OH) and was markedly greater than that of (112)-faceted CuFeSe2, with nearly 100% of Staphylococcus aureus being killed under near-infrared (NIR) irradiation. Importantly, bacteria-pretreated immune membranes (i.e., pathogen receptor membranes) coated with CuFeSe2 exhibited superior S. aureus-binding ability, presented obvious immune-evading capability, and resulted in targeted delivery to infected sites. As a proof-of-principle demonstration, these findings hold promise for the use of pathogen receptor membrane-coated facet-dependent nanomaterials in clinical applications and the treatment of bacterial infections.