Dialyzable Carbosilane Dendrimers as Soluble Supports for the Functionalization of Pyridine Fragments via Palladium-Catalyzed Coupling Reactions

The use of carbosilane (CS) dendrimers as soluble supports in liquid phase organic synthesis (LPOS) is described. Control of the three key steps is perfectly achieved by covalently binding a pyridine fragment to the soluble support, modifying it via coupling reactions, and releasing it at the end. N...

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Bibliographic Details
Published inOrganic letters Vol. 7; no. 3; pp. 363 - 366
Main Authors Le Nôtre, Jérôme, Firet, Judith J., Sliedregt, Leo A. J. M., van Steen, Bart J., van Koten, Gerard, Klein Gebbink, Robertus J. M.
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 03.02.2005
Amer Chemical Soc
Subjects
Catalysis
Chemistry
Chemistry, Organic
Dendrimers
Dialysis
Palladium - chemistry
Physical Sciences
Pyridines - chemistry
Science & Technology
Silanes - chemistry
Solubility
Trimethylsilyl Compounds - chemistry
REGIOSELECTIVE ORTHO-LITHIATION
COMPLEXES
SOLID-PHASE
CHEMISTRY
SMALL-MOLECULE LIBRARIES
PHASE ORGANIC-SYNTHESIS
HALOPYRIDINES
POLYMER SUPPORTS
DERIVATIVES
UTILITY
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Summary:The use of carbosilane (CS) dendrimers as soluble supports in liquid phase organic synthesis (LPOS) is described. Control of the three key steps is perfectly achieved by covalently binding a pyridine fragment to the soluble support, modifying it via coupling reactions, and releasing it at the end. Nanofiltration (dialysis) allows facile purification of the supported molecules after each step.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol0480776