Abietane Diterpenoids from the Roots of Clerodendrum trichotomum and Their Nitric Oxide Inhibitory Activities

Twelve new abietane diterpenoids (1–12) and 31 known analogues (13–43) were isolated from a medicinal Chinese herb, Clerodendrum trichotomum Thunberg. The absolute configurations of 1–3 were established on the basis of ECD and X-ray crystallography data, whereas that of 4 was elucidated by compariso...

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Published inJournal of natural products (Washington, D.C.) Vol. 81; no. 7; pp. 1508 - 1516
Main Authors Hu, Hai-Jun, Zhou, Yue, Han, Zhu-Zhen, Shi, Yan-Hong, Zhang, Shu-Sheng, Wang, Zheng-Tao, Yang, Li
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society and American Society of Pharmacognosy 27.07.2018
Amer Chemical Soc
Subjects
Chemistry, Medicinal
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Plant Sciences
Science & Technology
PHENYLPROPANOID GLYCOSIDES
FLAVONOIDS
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Summary:Twelve new abietane diterpenoids (1–12) and 31 known analogues (13–43) were isolated from a medicinal Chinese herb, Clerodendrum trichotomum Thunberg. The absolute configurations of 1–3 were established on the basis of ECD and X-ray crystallography data, whereas that of 4 was elucidated by comparison of experimental and calculated ECD data. Eight diterpenoids, 15,16-dehydroteuvincenone G (1), trichotomin A (4), 2α-hydrocaryopincaolide F (7), villosin C (20), 15-dehydro-17-hydroxycyrtophyllone A (22), demethylcryptojaponol (38), 6β-hydroxydemethylcryptojaponol (39), and trichotomone (43), exerted inhibitory effects against NO production with IC50 values of 5.6–16.1 μM. The structure–activity relationships of the isolated diterpenoids are also estimated.
Bibliography:ObjectType-Article-1
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ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.7b00814