Parvifoline Derivatives as Tubulin Polymerization Inhibitors

• Published in: Journal of natural products (Washington, D.C.) Vol. 82; no. 4; pp. 840 - 849
• Main Authors: Silva-García, Edna M, Cerda-García-Rojas, Carlos M, del Río, Rosa E, Joseph-Nathan, Pedro
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society and American Society of Pharmacognosy 26.04.2019; Amer Chemical Soc
• Subjects: Chemistry, Medicinal; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Plant Sciences; Science & Technology; SESQUITERPENES; PROVIDE; COLCHICINE BINDING-SITE; ALPHA-TUBULIN

A series of functionalized sesquiterpenoids derived from benzocyclooctene, including natural parvifoline (1), isoparvifoline (3), epoxyparvifoline (5), epoxyisoparvifoline (7), 8,12-oxyparfivoline (9), 8,14-oxyparvifoline (11), and the respective benzoyl derivatives 2, 4, 6, 8, 10, and 12, were prep...