Metabolism of Antifungal Thiochroman-4-ones by Trichoderma viride and Botrytis cinerea

Biotransformation of 6-methylthiochroman-4-one (1) and 6-chlorothiochroman-4-one (2) was performed using Trichoderma viride in order to obtain new derivatives with antifungal properties against the phytopathogen Botrytis cinerea. Two thiochromanone derivatives are described for the first time. Antif...

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Published inJournal of natural products (Washington, D.C.) Vol. 81; no. 4; pp. 1036 - 1040
Main Authors Pinedo-Rivilla, Cristina, Collado, Isidro G, Aleu, Josefina
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society and American Society of Pharmacognosy 27.04.2018
Amer Chemical Soc
Subjects
Antifungal Agents - metabolism
Antifungal Agents - pharmacology
Biotransformation
Botrytis - drug effects
Chemistry, Medicinal
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Plant Diseases - microbiology
Plant Sciences
Science & Technology
Trichoderma - metabolism
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Summary:Biotransformation of 6-methylthiochroman-4-one (1) and 6-chlorothiochroman-4-one (2) was performed using Trichoderma viride in order to obtain new derivatives with antifungal properties against the phytopathogen Botrytis cinerea. Two thiochromanone derivatives are described for the first time. Antifungal activity of these compounds was tested against two different strains of Botrytis cinerea; 1 and 2 gave 100% inhibition of Bc2100 at 100–250 μg/mL, and 3 gave a maximal inhibition of 96% of BcUCA992 at 200 μg/mL. The detoxification mechanism of 1 and 2 by B. cinerea was also investigated.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.7b00298